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Joanne K Hobbs
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On the temperature dependence of enzyme-catalyzed rates
VL Arcus, EJ Prentice, JK Hobbs, AJ Mulholland, MW Van der Kamp, ...
Biochemistry 55 (12), 1681-1688, 2016
2812016
Thermodynamic theory explains the temperature optima of soil microbial processes and high Q10 values at low temperatures
LA Schipper, JK Hobbs, S Rutledge, VL Arcus
Global change biology 20 (11), 3578-3586, 2014
2152014
Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates
JK Hobbs, W Jiao, AD Easter, EJ Parker, LA Schipper, VL Arcus
ACS chemical biology 8 (11), 2388-2393, 2013
2032013
Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus
JK Hobbs, K Miller, AJ O’Neill, I Chopra
Journal of Antimicrobial Chemotherapy 62 (5), 1003-1008, 2008
1642008
On the Origin and Evolution of Thermophily: Reconstruction of Functional Precambrian Enzymes from Ancestors of Bacillus
JK Hobbs, C Shepherd, DJ Saul, NJ Demetras, S Haaning, CR Monk, ...
Molecular biology and evolution 29 (2), 825-835, 2012
1142012
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity
N Ooi, K Miller, J Hobbs, W Rhys-Williams, W Love, I Chopra
Journal of antimicrobial chemotherapy 64 (4), 735-740, 2009
1082009
(p) ppGpp and the stringent response: an emerging threat to antibiotic therapy
JK Hobbs, AB Boraston
ACS infectious diseases 5 (9), 1505-1517, 2019
802019
KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate
JK Hobbs, SM Lee, M Robb, F Hof, C Barr, KT Abe, JH Hehemann, ...
Proceedings of the National Academy of Sciences 113 (22), 6188-6193, 2016
732016
Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence
M Robb, JK Hobbs, SA Woodiga, S Shapiro-Ward, MDL Suits, ...
PLoS pathogens 13 (1), e1006090, 2017
702017
Toward more accurate ancestral protein genotype–phenotype reconstructions with the use of species tree-aware gene trees
M Groussin, JK Hobbs, GJ Szöllősi, S Gribaldo, VL Arcus, M Gouy
Molecular Biology and Evolution 32 (1), 13-22, 2015
482015
Insights into the κ/ι-carrageenan metabolism pathway of some marine Pseudoalteromonas species
AG Hettle, JK Hobbs, B Pluvinage, C Vickers, KT Abe, O Salama-Alber, ...
Communications biology 2 (1), 474, 2019
472019
Glycan‐metabolizing enzymes in microbe–host interactions: the Streptococcus pneumoniae paradigm
JK Hobbs, B Pluvinage, AB Boraston
FEBS letters 592 (23), 3865-3897, 2018
432018
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
SD Baines, AR Noel, GS Huscroft, SL Todhunter, R O'Connor, JK Hobbs, ...
Journal of antimicrobial chemotherapy 66 (7), 1537-1546, 2011
382011
Biochemical reconstruction of a metabolic pathway from a marine bacterium reveals its mechanism of pectin depolymerization
JK Hobbs, AG Hettle, C Vickers, AB Boraston
Applied and Environmental Microbiology 85 (1), e02114-18, 2019
272019
A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans
M Robb, CS Robb, MA Higgins, JK Hobbs, JC Paton, AB Boraston
Journal of Biological Chemistry 290 (52), 30888-30900, 2015
232015
Metabolism of a hybrid algal galactan by members of the human gut microbiome
CS Robb, JK Hobbs, B Pluvinage, G Reintjes, L Klassen, S Monteith, ...
Nature chemical biology 18 (5), 501-510, 2022
222022
Reconstructed ancestral enzymes impose a fitness cost upon modern bacteria despite exhibiting favourable biochemical properties
JK Hobbs, EJ Prentice, M Groussin, VL Arcus
Journal of molecular evolution 81, 110-120, 2015
222015
Two complementary α-fucosidases from Streptococcus pneumoniae promote complete degradation of host-derived carbohydrate antigens
JK Hobbs, B Pluvinage, M Robb, SP Smith, AB Boraston
Journal of Biological Chemistry 294 (34), 12670-12682, 2019
192019
Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus
D Bryson, AG Hettle, AB Boraston, JK Hobbs
Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 02103-19, 2020
182020
Functional analyses of resurrected and contemporary enzymes illuminate an evolutionary path for the emergence of exolysis in polysaccharide lyase family 2
R McLean, JK Hobbs, MD Suits, ST Tuomivaara, DR Jones, AB Boraston, ...
Journal of Biological Chemistry 290 (35), 21231-21243, 2015
172015
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