Joanne K Hobbs
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On the temperature dependence of enzyme-catalyzed rates
VL Arcus, EJ Prentice, JK Hobbs, AJ Mulholland, MW Van der Kamp, ...
Biochemistry 55 (12), 1681-1688, 2016
Thermodynamic theory explains the temperature optima of soil microbial processes and high Q10 values at low temperatures
LA Schipper, JK Hobbs, S Rutledge, VL Arcus
Global change biology 20 (11), 3578-3586, 2014
Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates
JK Hobbs, W Jiao, AD Easter, EJ Parker, LA Schipper, VL Arcus
ACS chemical biology 8 (11), 2388-2393, 2013
Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus
JK Hobbs, K Miller, AJ O’Neill, I Chopra
Journal of Antimicrobial Chemotherapy 62 (5), 1003-1008, 2008
On the Origin and Evolution of Thermophily: Reconstruction of Functional Precambrian Enzymes from Ancestors of Bacillus
JK Hobbs, C Shepherd, DJ Saul, NJ Demetras, S Haaning, CR Monk, ...
Molecular biology and evolution 29 (2), 825-835, 2012
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity
N Ooi, K Miller, J Hobbs, W Rhys-Williams, W Love, I Chopra
Journal of antimicrobial chemotherapy 64 (4), 735-740, 2009
(p) ppGpp and the stringent response: an emerging threat to antibiotic therapy
JK Hobbs, AB Boraston
ACS infectious diseases 5 (9), 1505-1517, 2019
KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate
JK Hobbs, SM Lee, M Robb, F Hof, C Barr, KT Abe, JH Hehemann, ...
Proceedings of the National Academy of Sciences 113 (22), 6188-6193, 2016
Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence
M Robb, JK Hobbs, SA Woodiga, S Shapiro-Ward, MDL Suits, ...
PLoS pathogens 13 (1), e1006090, 2017
Toward more accurate ancestral protein genotype–phenotype reconstructions with the use of species tree-aware gene trees
M Groussin, JK Hobbs, GJ Szöllősi, S Gribaldo, VL Arcus, M Gouy
Molecular Biology and Evolution 32 (1), 13-22, 2015
Insights into the κ/ι-carrageenan metabolism pathway of some marine Pseudoalteromonas species
AG Hettle, JK Hobbs, B Pluvinage, C Vickers, KT Abe, O Salama-Alber, ...
Communications biology 2 (1), 474, 2019
Glycan‐metabolizing enzymes in microbe–host interactions: the Streptococcus pneumoniae paradigm
JK Hobbs, B Pluvinage, AB Boraston
FEBS letters 592 (23), 3865-3897, 2018
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
SD Baines, AR Noel, GS Huscroft, SL Todhunter, R O'Connor, JK Hobbs, ...
Journal of antimicrobial chemotherapy 66 (7), 1537-1546, 2011
Biochemical reconstruction of a metabolic pathway from a marine bacterium reveals its mechanism of pectin depolymerization
JK Hobbs, AG Hettle, C Vickers, AB Boraston
Applied and Environmental Microbiology 85 (1), e02114-18, 2019
A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans
M Robb, CS Robb, MA Higgins, JK Hobbs, JC Paton, AB Boraston
Journal of Biological Chemistry 290 (52), 30888-30900, 2015
Metabolism of a hybrid algal galactan by members of the human gut microbiome
CS Robb, JK Hobbs, B Pluvinage, G Reintjes, L Klassen, S Monteith, ...
Nature chemical biology 18 (5), 501-510, 2022
Reconstructed ancestral enzymes impose a fitness cost upon modern bacteria despite exhibiting favourable biochemical properties
JK Hobbs, EJ Prentice, M Groussin, VL Arcus
Journal of molecular evolution 81, 110-120, 2015
Two complementary α-fucosidases from Streptococcus pneumoniae promote complete degradation of host-derived carbohydrate antigens
JK Hobbs, B Pluvinage, M Robb, SP Smith, AB Boraston
Journal of Biological Chemistry 294 (34), 12670-12682, 2019
Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus
D Bryson, AG Hettle, AB Boraston, JK Hobbs
Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 02103-19, 2020
Functional analyses of resurrected and contemporary enzymes illuminate an evolutionary path for the emergence of exolysis in polysaccharide lyase family 2
R McLean, JK Hobbs, MD Suits, ST Tuomivaara, DR Jones, AB Boraston, ...
Journal of Biological Chemistry 290 (35), 21231-21243, 2015
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