| Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes LE Edgington, AB Berger, G Blum, VE Albrow, MG Paulick, N Lineberry, ... Nature medicine 15 (8), 967-973, 2009 | 328 | 2009 |
| Cathepsin B inhibition limits bone metastasis in breast cancer NP Withana, G Blum, M Sameni, C Slaney, A Anbalagan, MB Olive, ... Cancer research 72 (5), 1199-1209, 2012 | 224 | 2012 |
| Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes LE Edgington, M Verdoes, M Bogyo Current opinion in chemical biology 15 (6), 798-805, 2011 | 192 | 2011 |
| Functional imaging of legumain in cancer using a new quenched activity-based probe LE Edgington, M Verdoes, A Ortega, NP Withana, J Lee, S Syed, ... Journal of the American Chemical Society 135 (1), 174-182, 2013 | 169 | 2013 |
| Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ... Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018 | 160 | 2018 |
| PD-1 inhibitory receptor downregulates asparaginyl endopeptidase and maintains Foxp3 transcription factor stability in induced regulatory T cells C Stathopoulou, A Gangaplara, G Mallett, FA Flomerfelt, LP Liniany, ... Immunity 49 (2), 247-263. e7, 2018 | 131 | 2018 |
| A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages M Verdoes, LE Edgington, FA Scheeren, M Leyva, G Blum, K Weiskopf, ... Chemistry & biology 19 (5), 619-628, 2012 | 119 | 2012 |
| Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity G Blum, RM Weimer, LE Edgington, W Adams, M Bogyo PLoS One 4 (7), e6374, 2009 | 119 | 2009 |
| Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity H Li, EL Ponder, M Verdoes, KH Asbjornsdottir, E Deu, LE Edgington, ... Chemistry & biology 19 (12), 1535-1545, 2012 | 95 | 2012 |
| Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis‐mediated therapy in a humanized death receptor mouse model J Li, HC Hsu, PA Yang, Q Wu, H Li, LE Edgington, M Bogyo, RP Kimberly, ... Arthritis & Rheumatism 64 (4), 1098-1109, 2012 | 77 | 2012 |
| An optimized activity-based probe for the study of caspase-6 activation LE Edgington, BJ Van Raam, M Verdoes, C Wierschem, GS Salvesen, ... Chemistry & biology 19 (3), 340-352, 2012 | 61 | 2012 |
| Myoepithelial cell‐specific expression of stefin A as a suppressor of early breast cancer invasion HM Duivenvoorden, J Rautela, LE Edgington‐Mitchell, A Spurling, ... The Journal of pathology 243 (4), 496-509, 2017 | 58 | 2017 |
| Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer LE Edgington-Mitchell, J Rautela, HM Duivenvoorden, KM Jayatilleke, ... Oncotarget 6 (29), 27008, 2015 | 51 | 2015 |
| Non-Invasive Imaging of Cysteine Cathepsin Activity in Solid Tumors Using a 64Cu-Labeled Activity-Based Probe G Ren, G Blum, M Verdoes, H Liu, S Syed, LE Edgington, O Gheysens, ... PloS one 6 (11), e28029, 2011 | 51 | 2011 |
| Legumain induces oral cancer pain by biased agonism of protease-activated receptor-2 NH Tu, DD Jensen, BM Anderson, E Chen, NN Jimenez-Vargas, ... Journal of Neuroscience 41 (1), 193-210, 2021 | 46 | 2021 |
| Protease-activated receptors in health and disease CJ Peach, LE Edgington-Mitchell, NW Bunnett, BL Schmidt Physiological Reviews 103 (1), 717-785, 2023 | 45 | 2023 |
| Lysosomal degradation products induce Coxiella burnetii virulence P Newton, DR Thomas, SCO Reed, N Lau, B Xu, SY Ong, S Pasricha, ... Proceedings of the National Academy of Sciences 117 (12), 6801-6810, 2020 | 43 | 2020 |
| The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells OV Razorenova, L Castellini, R Colavitti, LE Edgington, M Nicolau, ... Molecular and cellular biology 34 (4), 739-751, 2014 | 40 | 2014 |
| Live cell imaging and profiling of cysteine cathepsin activity using a quenched activity-based probe LE Edgington-Mitchell, M Bogyo, M Verdoes Activity-Based Proteomics: Methods and Protocols, 145-159, 2017 | 39 | 2017 |
| Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation LE Edgington-Mitchell, N Barlow, L Aurelio, A Samha, M Szabo, ... Bioorganic & medicinal chemistry letters 27 (2), 254-260, 2017 | 36 | 2017 |
Matthew BogyoProfessor of Pathology, Stanford UniversityVerified email at stanford.edu
