Tove Sjögren
Tove Sjögren
Director, AstraZeneca R&D, Discovery Sciences
Verified email at
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Structural basis for ligand promiscuity in cytochrome P450 3A4
M Ekroos, T Sjögren
Proceedings of the National Academy of Sciences 103 (37), 13682-13687, 2006
Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro
M Pihlgren, PM Dubois, M Tomkowiak, T Sjögren, J Marvel
The Journal of experimental medicine 184 (6), 2141-2152, 1996
2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation
AK Tidén, T Sjögren, M Svensson, A Bernlind, R Senthilmohan, ...
Journal of Biological Chemistry 286 (43), 37578-37589, 2011
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily
T Sjögren, J Nord, M Ek, P Johansson, G Liu, S Geschwindner
Proceedings of the National Academy of Sciences 110 (10), 3806-3811, 2013
Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold
CK Wang, SH Hu, JL Martin, T Sjogren, J Hajdu, L Bohlin, P Claeson, ...
Journal of Biological Chemistry 284 (16), 10672-10683, 2009
Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates
LV Forbes, T Sjögren, F Auchère, DW Jenkins, B Thong, D Laughton, ...
Journal of Biological Chemistry 288 (51), 36636-36647, 2013
Analyzing protein functions in four dimensions
J Hajdu, R Neutze, T Sjögren, K Edman, A Szöke, RC Wilmouth, ...
nature structural biology 7 (11), 1006-1012, 2000
Structural and functional characterization of a specific antidote for ticagrelor
A Buchanan, P Newton, S Pehrsson, T Inghardt, T Antonsson, ...
Blood, The Journal of the American Society of Hematology 125 (22), 3484-3490, 2015
Structure-based ligand design to overcome CYP inhibition in drug discovery projects
G Brändén, T Sjögren, V Schnecke, Y Xue
Drug discovery today 19 (7), 905-911, 2014
Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors
ZHJ Wang T, Lamb ML, Block MH, Davies AM, Han Y, Hoffmann E, Ioannidis S ...
ACS Med Chem Lett., 2012
Quantum Mechanical Interpretation of Nitrite Reduction by Cytochrome cd1 Nitrite Reductase from Paracoccus pantotrophus
G Ranghino, E Scorza, T Sjögren, PA Williams, M Ricci, J Hajdu
Biochemistry 39 (36), 10958-10966, 2000
Defining Redox State of X-Ray Crystal Structures by Single-Crystal Ultraviolet–Visible Microspectrophotometry
CM Wilmot, T Sjögren, GH Carlsson, GI Berglund, J Hajdu
Methods in enzymology 353, 301-318, 2002
Structure of the Bound Dioxygen Species in the Cytochrome Oxidase Reaction of Cytochrome cd1Nitrite Reductase
T Sjögren, J Hajdu
Journal of Biological Chemistry 276 (16), 13072-13076, 2001
Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1
JA Douthwaite, S Sridharan, C Huntington, J Hammersley, R Marwood, ...
MAbs 7 (1), 152-166, 2015
Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation
O Fjellström, J Deinum, T Sjögren, C Johansson, S Geschwindner, ...
Journal of Biological Chemistry 288 (2), 873-885, 2013
Structure and kinetic properties of Paracoccus pantotrophus cytochrome cd1 nitrite reductase with the d1 heme active site ligand tyrosine 25 replaced by serine
EHJ Gordon, T Sjögren, M Löfqvist, CD Richter, JWA Allen, ...
Journal of Biological Chemistry 278 (14), 11773-11781, 2003
FragMAX: the fragment-screening platform at the MAX IV Laboratory
GMA Lima, VO Talibov, E Jagudin, C Sele, M Nyblom, W Knecht, ...
Acta Crystallographica Section D: Structural Biology 76 (8), 771-777, 2020
The Structure of an Alternative Form ofParacoccus pantotrophus Cytochromecd 1 Nitrite Reductase
T Sjögren, J Hajdu
Journal of Biological Chemistry 276 (31), 29450-29455, 2001
Protein crystallography in a vapour stream: data collection, reaction initiation and intermediate trapping in naked hydrated protein crystals
T Sjögren, G Carlsson, G Larsson, A Hajdu, C Andersson, H Pettersson, ...
Journal of applied crystallography 35 (1), 113-116, 2002
Optimization of brain penetrant 11β-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice
FW Goldberg, AG Dossetter, JS Scott, GR Robb, S Boyd, SD Groombridge, ...
Journal of Medicinal Chemistry 57 (3), 970-986, 2014
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