J Woolard
J Woolard
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VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
J Woolard, WY Wang, HS Bevan, Y Qiu, L Morbidelli, RO Pritchard-Jones, ...
Cancer research 64 (21), 7822-7835, 2004
Expression of pro-and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
DG Nowak, J Woolard, EM Amin, O Konopatskaya, MA Saleem, ...
Journal of cell science 121 (20), 3487-3495, 2008
Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
CJ Peach, VW Mignone, MA Arruda, DC Alcobia, SJ Hill, LE Kilpatrick, ...
International journal of molecular sciences 19 (4), 1264, 2018
Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
DG Nowak, EM Amin, ES Rennel, C Hoareau-Aveilla, M Gammons, ...
Journal of Biological Chemistry 285 (8), 5532-5540, 2010
The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
ES Rennel, E Waine, H Guan, Y Schüler, W Leenders, J Woolard, ...
British journal of cancer 98 (7), 1250-1257, 2008
Molecular diversity of VEGF-A as a regulator of its biological activity
J Woolard, HS Bevan, SJ Harper, DO Bates
Microcirculation 16 (7), 572-592, 2009
Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization
SJ Hill, LT May, B Kellam, J Woolard
British Journal of Pharmacology 171 (5), 1102-1113, 2014
Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor …
LE Kilpatrick, R Friedman-Ohana, DC Alcobia, K Riching, CJ Peach, ...
Biochemical Pharmacology 136, 62-75, 2017
Role of the renin–angiotensin–aldosterone and kinin–kallikrein systems in the cardiovascular complications of COVID-19 and long COVID
SL Cooper, E Boyle, SR Jefferson, CRA Heslop, P Mohan, GGJ Mohanraj, ...
International Journal of Molecular Sciences 22 (15), 8255, 2021
Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β1‐adrenoceptor expressed …
M Soave, LA Stoddart, A Brown, J Woolard, SJ Hill
Pharmacology Research & Perspectives 4 (5), e00250, 2016
NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization
M Soave, B Kellam, J Woolard, SJ Briddon, SJ Hill
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (2), 186-194, 2020
Real-time ligand binding of fluorescent VEGF-A isoforms that discriminate between VEGFR2 and NRP1 in living cells
CJ Peach, LE Kilpatrick, R Friedman-Ohana, K Zimmerman, MB Robers, ...
Cell chemical biology 25 (10), 1208-1218. e5, 2018
Complex Formation between VEGFR2 and the β2-Adrenoceptor
LE Kilpatrick, DC Alcobia, CW White, CJ Peach, JR Glenn, K Zimmerman, ...
Cell Chemical Biology 26 (6), 830-841. e9, 2019
Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment
CJ Hutchings, G Cseke, G Osborne, J Woolard, A Zhukov, M Koglin, ...
MAbs 6 (1), 246-261, 2014
A perspective on studying G-protein–coupled receptor signaling with resonance energy transfer biosensors in living organisms
J van Unen, J Woolard, A Rinken, C Hoffmann, SJ Hill, J Goedhart, ...
Molecular pharmacology 88 (3), 589-595, 2015
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms
J Woolard, W Vousden, SJ Moss, A Krishnakumar, MVR Gammons, ...
Chemical Science 2 (2), 273-278, 2011
Visualizing ligand binding to a GPCR in vivo using NanoBRET
DC Alcobia, AI Ziegler, A Kondrashov, E Comeo, S Mistry, B Kellam, ...
Iscience 6, 280-288, 2018
Acute cardiovascular effects of sibutramine in conscious rats
J Woolard, T Bennett, WR Dunn, DJ Heal, S Aspley, SM Gardiner
Journal of Pharmacology and Experimental Therapeutics 308 (3), 1102-1110, 2004
Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells
LA Stoddart, ND Kindon, O Otun, CR Harwood, F Patera, DB Veprintsev, ...
Communications biology 3 (1), 722, 2020
Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats
JJ Carter, LV Fretwell, J Woolard
The FASEB Journal 31 (3), 1193, 2017
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