Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods K Tsaioun, BJ Blaauboer, T Hartung ALTEX-Alternatives to animal experimentation 33 (4), 343-358, 2016 | 111 | 2016 |
ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective K Tsaioun, M Bottlaender, A Mabondzo, ... BMC neurology 9 (Suppl 1), S1, 2009 | 106 | 2009 |
GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence—An overview in the context of health decision-making JL Brozek, C Canelo-Aybar, EA Akl, JM Bowen, J Bucher, WA Chiu, ... Journal of clinical epidemiology 129, 138-150, 2021 | 96 | 2021 |
A primer on systematic reviews in toxicology S Hoffmann, RBM de Vries, ML Stephens, NB Beck, HAAM Dirven, ... Archives of toxicology 91, 2551-2575, 2017 | 81 | 2017 |
ADMET for medicinal chemists: a practical guide K Tsaioun, SA Kates John Wiley & Sons, 2011 | 75 | 2011 |
Software tools for literature screening in systematic reviews in biomedical research S Van der Mierden, K Tsaioun, A Bleich, CHC Leenaars ALTEX-Alternatives to animal experimentation 36 (3), 508-517, 2019 | 72 | 2019 |
Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates JK Gwathmey, K Tsaioun, RJ Hajjar Expert opinion on drug metabolism & toxicology 5 (6), 647-660, 2009 | 68 | 2009 |
QSAR-based permeability model for drug-like compounds R Gozalbes, M Jacewicz, R Annand, K Tsaioun, A Pineda-Lucena Bioorganic & medicinal chemistry 19 (8), 2615-2624, 2011 | 60 | 2011 |
Toward good in vitro reporting standards T Hartung, R De Vries, S Hoffmann, HT Hogberg, L Smirnova, K Tsaioun, ... ALTEX-Alternatives to animal experimentation 36 (1), 3-17, 2019 | 55 | 2019 |
Probabilistic risk assessment–the keystone for the future of toxicology A Maertens, E Golden, TH Luechtefeld, S Hoffmann, K Tsaioun, T Hartung Altex 39 (1), 3, 2022 | 42 | 2022 |
Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges H Geerts, J Wikswo, PH van der Graaf, JPF Bai, C Gaiteri, D Bennett, ... CPT: pharmacometrics & systems pharmacology 9 (1), 5-20, 2020 | 39 | 2020 |
Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review H Dirven, GE Vist, S Bandhakavi, J Mehta, SE Fitch, P Pound, R Ram, ... Scientific reports 11 (1), 6403, 2021 | 30 | 2021 |
Better science for safer medicines: the human imperative K Archibald, K Tsaioun, JG Kenna, P Pound Journal of the Royal Society of Medicine 111 (12), 433-438, 2018 | 28 | 2018 |
De-Risking Drug Discovery with ADDME — Avoiding Drug Development Mistakes Early K Tsaioun, M Jacewicz Alternatives to Laboratory Animals 37 (1_suppl), 47-55, 2009 | 24 | 2009 |
The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review B Henschenmacher, A Bitsch, T de Las Heras Gala, HJ Forman, ... Environment international 158, 106932, 2022 | 21 | 2022 |
Reviewing the animal literature: how to describe and choose between different types of literature reviews C Leenaars, K Tsaioun, F Stafleu, K Rooney, F Meijboom, ... Laboratory Animals 55 (2), 129-141, 2021 | 20 | 2021 |
Biological plausibility in environmental health systematic reviews: a GRADE concept paper P Whaley, T Piggott, RL Morgan, S Hoffmann, K Tsaioun, ... Environment international 162, 107109, 2022 | 18 | 2022 |
Drug discovery and development: introduction to the general public and patient groups N Singh, P Vayer, S Tanwar, JL Poyet, K Tsaioun, BO Villoutreix Frontiers in Drug Discovery 3, 1201419, 2023 | 15 | 2023 |
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease–3rd CIAO AOP Design Workshop LA Clerbaux, N Amigó, MJ Amorim, A Bal-Price, SB Leite, A Beronius, ... Altex 39 (2), 322–335, 2022 | 15 | 2022 |
First Organoid Intelligence (OI) workshop to form an OI community IE Morales Pantoja, L Smirnova, AR Muotri, KJ Wahlin, J Kahn, JL Boyd, ... Frontiers in Artificial Intelligence 6, 1116870, 2023 | 14 | 2023 |