| Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control I Barbieri, K Tzelepis, L Pandolfini, J Shi, G Millán-Zambrano, SC Robson, ... Nature 552 (7683), 126-131, 2017 | 834 | 2017 |
| A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ... Cell reports 17 (4), 1193-1205, 2016 | 589 | 2016 |
| Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia E Yankova, W Blackaby, M Albertella, J Rak, E De Braekeleer, ... Nature 593 (7860), 597-601, 2021 | 490 | 2021 |
| RNA modifications detection by comparative Nanopore direct RNA sequencing A Leger, PP Amaral, L Pandolfini, C Capitanchik, F Capraro, V Miano, ... Nature communications 12 (1), 7198, 2021 | 196 | 2021 |
| METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, ... Molecular cell 81 (16), 3323-3338. e14, 2021 | 146 | 2021 |
| Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition P Gallipoli, G Giotopoulos, K Tzelepis, ASH Costa, S Vohra, ... Blood, The Journal of the American Society of Hematology 131 (15), 1639-1653, 2018 | 139 | 2018 |
| Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ... Leukemia 31 (3), 720-727, 2017 | 133 | 2017 |
| UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs M Gozdecka, E Meduri, M Mazan, K Tzelepis, M Dudek, AJ Knights, ... Nature genetics 50 (6), 883-894, 2018 | 130 | 2018 |
| Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia OM Dovey, JL Cooper, A Mupo, CS Grove, C Lynn, N Conte, RM Andrews, ... Blood, The Journal of the American Society of Hematology 130 (17), 1911-1922, 2017 | 64 | 2017 |
| SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 K Tzelepis, E De Braekeleer, D Aspris, I Barbieri, MS Vijayabaskar, ... Nature communications 9 (1), 5378, 2018 | 62 | 2018 |
| Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality R Szmyd, J Niska-Blakie, MK Diril, P Renck Nunes, K Tzelepis, A Lacroix, ... Oncogene 38 (7), 998-1018, 2019 | 59 | 2019 |
| Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries E Metzakopian, A Strong, V Iyer, A Hodgkins, K Tzelepis, L Antunes, ... Scientific reports 7 (1), 2244, 2017 | 42 | 2017 |
| meCLICK-Seq, a substrate-hijacking and RNA degradation strategy for the study of RNA methylation S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, ... ACS central science 6 (12), 2196-2208, 2020 | 39 | 2020 |
| Cyclin D1 in invasive breast carcinoma: favourable prognostic significance in unselected patients and within subgroups with an aggressive phenotype E Mylona, K Tzelepis, I Theohari, I Giannopoulou, C Papadimitriou, ... Histopathology 62 (3), 472-480, 2013 | 38 | 2013 |
| Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies N Han, W Hwang, K Tzelepis, P Schmerer, E Yankova, M MacMahon, ... Science Advances 7 (27), eabh3032, 2021 | 37 | 2021 |
| KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements YZ Au, M Gu, E De Braekeleer, M Gozdecka, D Aspris, Y Tarumoto, ... Leukemia 35 (4), 1012-1022, 2021 | 29 | 2021 |
| RNA-modifying enzymes and their function in a chromatin context K Tzelepis, O Rausch, T Kouzarides Nature structural & molecular biology 26 (10), 858-862, 2019 | 26 | 2019 |
| Effect of BRCA1 immunohistochemical localizations on prognosis of patients with sporadic breast carcinomas E Mylona, S Melissaris, A Nomikos, I Theohari, I Giannopoulou, ... Pathology-Research and Practice 210 (8), 533-540, 2014 | 23 | 2014 |
| Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication H Santos-Rosa, G Millan-Zambrano, N Han, T Leonardi, M Klimontova, ... Molecular cell 81 (13), 2793-2807. e8, 2021 | 18 | 2021 |
| Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML S Basilico, X Wang, A Kennedy, K Tzelepis, G Giotopoulos, SJ Kinston, ... Nature Communications 11 (1), 1407, 2020 | 16 | 2020 |
