| USP7 small-molecule inhibitors interfere with ubiquitin binding L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark, J Drummond, ... Nature 550 (7677), 534-538, 2017 | 284 | 2017 |
| Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152) JA Flygare, M Beresini, N Budha, H Chan, IT Chan, S Cheeti, F Cohen, ... Journal of medicinal chemistry 55 (9), 4101-4113, 2012 | 266 | 2012 |
| Inhibitors of IAP F Cohen, K Deshayes, WJ Fairbrother, B Feng, JA Flygare, LJ Gazzard, ... US Patent 7,244,851, 2007 | 128 | 2007 |
| Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck A Olszewski, K Sato, ZD Aron, F Cohen, A Harris, BR McDougall, ... Proceedings of the National Academy of Sciences 101 (39), 14079-14084, 2004 | 87 | 2004 |
| Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models S Patel, F Cohen, BJ Dean, K De La Torre, G Deshmukh, AA Estrada, ... Journal of medicinal chemistry 58 (1), 401-418, 2015 | 81 | 2015 |
| Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold F Cohen, B Alicke, LO Elliott, JA Flygare, T Goncharov, SF Keteltas, ... Journal of medicinal chemistry 52 (6), 1723-1730, 2009 | 78 | 2009 |
| Asymmetric total synthesis of batzelladine D F Cohen, LE Overman, SK Ly Sakata Organic letters 1 (13), 2169-2172, 1999 | 74 | 1999 |
| Optimization of LpxC inhibitors for antibacterial activity and cardiovascular safety F Cohen, JB Aggen, LD Andrews, Z Assar, J Boggs, T Choi, P Dozzo, ... ChemMedChem 14 (16), 1560-1572, 2019 | 69 | 2019 |
| Discovery of small-molecule inhibitors of ubiquitin specific protease 7 (USP7) using integrated NMR and in silico techniques P Di Lello, R Pastor, JM Murray, RA Blake, F Cohen, TD Crawford, ... Journal of medicinal chemistry 60 (24), 10056-10070, 2017 | 69 | 2017 |
| Enantioselective total synthesis of batzelladine F and definition of its structure F Cohen, LE Overman Journal of the American Chemical Society 128 (8), 2604-2608, 2006 | 67 | 2006 |
| Evolution of a strategy for the synthesis of structurally complex batzelladine alkaloids. Enantioselective total synthesis of the proposed structure of batzelladine F and … F Cohen, LE Overman Journal of the American Chemical Society 128 (8), 2594-2603, 2006 | 64 | 2006 |
| Azabicyclo-octane inhibitors of IAP F Cohen, W Fairbrother, J Flygare, SF Keteltas, VHW Tsui US Patent 7,345,081, 2008 | 63 | 2008 |
| Inhibition of HIV-1 envelope-mediated fusion by synthetic batzelladine analogues CA Bewley, S Ray, F Cohen, SK Collins, LE Overman Journal of natural products 67 (8), 1319-1324, 2004 | 62 | 2004 |
| Stereoselection in the Prins-pinacol synthesis of acyltetrahydrofurans F Cohen, DWC MacMillan, LE Overman, A Romero Organic letters 3 (8), 1225-1228, 2001 | 55 | 2001 |
| Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres F Cohen, MFT Koehler, P Bergeron, LO Elliott, JA Flygare, MC Franklin, ... Bioorganic & Medicinal Chemistry Letters 20 (7), 2229-2233, 2010 | 46 | 2010 |
| Discovery and biological profiling of potent and selective mTOR inhibitor GDC-0349 Z Pei, E Blackwood, L Liu, S Malek, M Belvin, MFT Koehler, DF Ortwine, ... ACS medicinal chemistry letters 4 (1), 103-107, 2013 | 45 | 2013 |
| Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa KM Krause, CM Haglund, C Hebner, AW Serio, G Lee, V Nieto, F Cohen, ... Antimicrobial agents and chemotherapy 63 (11), 10.1128/aac. 00977-19, 2019 | 44 | 2019 |
| Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 CE Heise, J Murray, KE Augustyn, B Bravo, P Chugha, F Cohen, ... PLoS One 7 (12), e50864, 2012 | 44 | 2012 |
| Targeting inhibitor of apoptosis proteins for therapeutic intervention C Ndubaku, F Cohen, E Varfolomeev, D Vucic Future medicinal chemistry 1 (8), 1509-1525, 2009 | 42 | 2009 |
| Pyrrolidine inhibitors of IAP F Cohen, V Tsui, C Ly, J Flygare US Patent App. 11/312,063, 2006 | 40 | 2006 |
