Jae Jin Chae
Jae Jin Chae
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ...
Nature medicine 21 (3), 248-255, 2015
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
GS Lee, N Subramanian, AI Kim, I Aksentijevich, R Goldbach-Mansky, ...
Nature 492 (7427), 123-127, 2012
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID …
I Aksentijevich, M Nowak, M Mallah, JJ Chae, WT Watford, SR Hofmann, ...
Arthritis & Rheumatism 46 (12), 3340-3348, 2002
Early-onset stroke and vasculopathy associated with mutations in ADA2
Q Zhou, D Yang, AK Ombrello, AV Zavialov, C Toro, AV Zavialov, ...
New England Journal of Medicine 370 (10), 911-920, 2014
The B30. 2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production
JJ Chae, G Wood, SL Masters, K Richard, G Park, BJ Smith, DL Kastner
Proceedings of the National Academy of Sciences 103 (26), 9982-9987, 2006
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease
DB Beck, MA Ferrada, KA Sikora, AK Ombrello, JC Collins, W Pei, ...
New England Journal of Medicine 383 (27), 2628-2638, 2020
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis
JJ Chae, HD Komarow, J Cheng, G Wood, N Raben, PP Liu, DL Kastner
Molecular cell 11 (3), 591-604, 2003
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ...
Nature genetics 48 (1), 67-73, 2016
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
YH Park, G Wood, DL Kastner, JJ Chae
Nature immunology 17 (8), 914-921, 2016
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice
JJ Chae, YH Cho, GS Lee, J Cheng, PP Liu, L Feigenbaum, SI Katz, ...
Immunity 34 (5), 755-768, 2011
Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the …
I Aksentijevich, Y Torosyan, J Samuels, M Centola, E Pras, JJ Chae, ...
The American Journal of Human Genetics 64 (4), 949-962, 1999
Familial mediterranean fever with a single MEFV mutation: Where is the second hit?
MG Booty, JJ Chae, SL Masters, EF Remmers, B Barham, JM Le, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2009
The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments
E Mansfield, JJ Chae, HD Komarow, TM Brotz, DM Frucht, I Aksentijevich, ...
Blood, The Journal of the American Society of Hematology 98 (3), 851-859, 2001
The pyrin inflammasome in health and disease
O Schnappauf, JJ Chae, DL Kastner, I Aksentijevich
Frontiers in immunology 10, 465008, 2019
Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy
JJ Chae, I Aksentijevich, DL Kastner
British journal of haematology 146 (5), 467-478, 2009
The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations
KM Hull, N Shoham, JJ Chae, I Aksentijevich, DL Kastner
Current opinion in rheumatology 15 (1), 61-69, 2003
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production
A Brehm, Y Liu, A Sheikh, B Marrero, E Omoyinmi, Q Zhou, ...
The Journal of clinical investigation 125 (11), 4196-4211, 2015
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
N Lalaoui, SE Boyden, H Oda, GM Wood, DL Stone, D Chau, L Liu, ...
Nature 577 (7788), 103-108, 2020
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
Q Zhou, X Yu, E Demirkaya, N Deuitch, D Stone, WL Tsai, HS Kuehn, ...
Proceedings of the National Academy of Sciences 113 (36), 10127-10132, 2016
Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
A Simon, H Park, R Maddipati, AA Lobito, AC Bulua, AJ Jackson, JJ Chae, ...
Proceedings of the National Academy of Sciences 107 (21), 9801-9806, 2010
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