Professor of Pathology, University of Tennessee Health Science Center
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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
O Nidai Ozes, LD Mayo, JA Gustin, SR Pfeffer, LM Pfeffer, DB Donner
Nature 401 (6748), 82-85, 1999
Biological properties of recombinant α-interferons: 40th anniversary of the discovery of interferons
LM Pfeffer, CA Dinarello, RB Herberman, BRG Williams, EC Borden, ...
Cancer research 58 (12), 2489-2499, 1998
The role of miR‐21 in cancer
SR Pfeffer, CH Yang, LM Pfeffer
Drug development research 76 (6), 270-277, 2015
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor
LM Pfeffer, JE Mullersman, SR Pfeffer, A Murti, W Shi, CH Yang
Science 276 (5317), 1418-1420, 1997
Interferon α/β promotes cell survival by activating nuclear factor κB through phosphatidylinositol 3-kinase and Akt
CH Yang, A Murti, SR Pfeffer, JG Kim, DB Donner, LM Pfeffer
Journal of Biological Chemistry 276 (17), 13756-13761, 2001
Activation of chemokine and inflammatory cytokine response in hepatitis C virus–infected hepatocytes depends on toll‐like receptor 3 sensing of hepatitis C virus doubleá…
K Li, NL Li, D Wei, SR Pfeffer, M Fan, LM Pfeffer
Hepatology 55 (3), 666-675, 2012
Induction of Jak/STAT signaling by activation of the type 1 TNF receptor
DQ Guo, JD Dunbar, CH Yang, LM Pfeffer, DB Donner
The Journal of Immunology 160 (6), 2742-2750, 1998
Interferon effects on microfilament organization cellular fibronectin distribution, and cell motility in human fibroblasts
LM Pfeffer, E Wang, I Tamm
The Journal of Cell Biology 85 (1), 9-17, 1980
MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells
CH Yang, J Yue, SR Pfeffer, CR Handorf, LM Pfeffer
Journal of Biological Chemistry 286 (45), 39172-39178, 2011
The role of nuclear factor κB in the interferon response
LM Pfeffer
Journal of Interferon & Cytokine Research 31 (7), 553-559, 2011
IFNα/β promotes cell survival by activating NF-κB
CH Yang, A Murti, SR Pfeffer, L Basu, JG Kim, LM Pfeffer
Proceedings of the National Academy of Sciences 97 (25), 13631-13636, 2000
IFN Induces miR-21 through a Signal transducer and activator of transcription 3–dependent pathway as a suppressive negative feedback on IFN-induced apoptosis
CH Yang, J Yue, M Fan, LM Pfeffer
Cancer research 70 (20), 8108-8116, 2010
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway
JM Garner, M Fan, CH Yang, Z Du, M Sims, AM Davidoff, LM Pfeffer
Journal of Biological Chemistry 288 (36), 26167-26176, 2013
Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo
NM Gharavi, JA Alva, KP Mouillesseaux, C Lai, M Yeh, W Yeung, ...
Journal of Biological Chemistry 282 (43), 31460-31468, 2007
DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion
J Niu, Y Shi, G Tan, CH Yang, M Fan, LM Pfeffer, ZH Wu
Journal of Biological Chemistry 287 (26), 21783-21795, 2012
Chromenes: potential new chemotherapeutic agents for cancer
SA Patil, R Patil, LM Pfeffer, DD Miller
Future medicinal chemistry 5 (14), 1647-1660, 2013
MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3)
CH Yang, J Yue, SR Pfeffer, M Fan, E Paulus, A Hosni-Ahmed, M Sims, ...
Journal of biological chemistry 289 (36), 25079-25087, 2014
STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities
CH Yang, A Murti, LM Pfeffer
Proceedings of the National Academy of Sciences 95 (10), 5568-5572, 1998
The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo
CH Yang, J Yue, M Sims, LM Pfeffer
PloS one 8 (8), e71130, 2013
Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor
CH Yang, W Shi, L Basu, A Murti, SN Constantinescu, L Blatt, E Croze, ...
Journal of Biological Chemistry 271 (14), 8057-8061, 1996
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