Luke Lairson
Luke Lairson
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Citované v
Citované v
Glycosyltransferases: structures, functions, and mechanisms
LL Lairson, B Henrissat, GJ Davies, SG Withers
Annu. Rev. Biochem. 77, 521-555, 2008
A regenerative approach to the treatment of multiple sclerosis
VA Deshmukh, V Tardif, CA Lyssiotis, CC Green, B Kerman, HJ Kim, ...
Nature 502 (7471), 327-332, 2013
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, ...
Proceedings of the National Academy of Sciences 106 (22), 8912-8917, 2009
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
E Mullarky, NC Lucki, R Beheshti Zavareh, JL Anglin, AP Gomes, ...
Proceedings of the National Academy of Sciences 113 (7), 1778-1783, 2016
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
EN Chin, C Yu, VF Vartabedian, Y Jia, M Kumar, AM Gamo, W Vernier, ...
Science 369 (6506), 993-999, 2020
High-throughput screening methodology for the directed evolution of glycosyltransferases
A Aharoni, K Thieme, CPC Chiu, S Buchini, LL Lairson, H Chen, ...
Nature Methods 3 (8), 609-614, 2006
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog
CPC Chiu, AG Watts, LL Lairson, M Gilbert, D Lim, WW Wakarchuk, ...
Nature structural & molecular biology 11 (2), 163-170, 2004
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
MJ Bollong, G Lee, JS Coukos, H Yun, C Zambaldo, JW Chang, EN Chin, ...
Nature 562 (7728), 600-604, 2018
An activity-guided map of electrophile-cysteine interactions in primary human T cells
EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ...
Cell 182 (4), 1009-1026. e29, 2020
Systems biology guided by XCMS Online metabolomics
T Huan, EM Forsberg, D Rinehart, CH Johnson, J Ivanisevic, HP Benton, ...
Nature methods 14 (5), 461-462, 2017
An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation
H Wurdak, S Zhu, A Romero, M Lorger, J Watson, C Chiang, J Zhang, ...
Cell stem cell 6 (1), 37-47, 2010
Chemical control of stem cell fate and developmental potential
CA Lyssiotis, LL Lairson, AE Boitano, H Wurdak, S Zhu, PG Schultz
Angewandte Chemie International Edition 50 (1), 200-242, 2011
A small molecule accelerates neuronal differentiation in the adult rat
H Wurdak, S Zhu, KH Min, L Aimone, LL Lairson, J Watson, G Chopiuk, ...
Proceedings of the National Academy of Sciences 107 (38), 16542-16547, 2010
Intermediate trapping on a mutant retaining α-galactosyltransferase identifies an unexpected aspartate residue
LL Lairson, CPC Chiu, HD Ly, S He, WW Wakarchuk, NCJ Strynadka, ...
Journal of Biological Chemistry 279 (27), 28339-28344, 2004
Mechanistic analogies amongst carbohydrate modifying enzymes
LL Lairson, SG Withers
Chemical communications, 2243-2248, 2004
Structural Analysis of the α-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms,
CPC Chiu, LL Lairson, M Gilbert, WW Wakarchuk, SG Withers, ...
Biochemistry 46 (24), 7196-7204, 2007
A small molecule inhibits deregulated NRF2 transcriptional activity in cancer
MJ Bollong, H Yun, L Sherwood, AK Woods, LL Lairson, PG Schultz
ACS chemical biology 10 (10), 2193-2198, 2015
Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation
BA Beyer, M Fang, B Sadrian, JR Montenegro-Burke, WC Plaisted, ...
Nature chemical biology 14 (1), 22-28, 2018
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis
LL Lairson, AG Watts, WW Wakarchuk, SG Withers
Nature Chemical Biology 2 (12), 724-728, 2006
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers
MJ Bollong, M Pietilä, AD Pearson, TR Sarkar, I Ahmad, R Soundararajan, ...
Proceedings of the National Academy of Sciences 114 (46), E9903-E9912, 2017
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Články 1–20