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Laura Jean Byrnes, Ph.D.
Laura Jean Byrnes, Ph.D.
Pfizer, Cornell University, Stanford Linear Accelerator Center, Rensselaer Polytechnic Institute
Verified email at cornell.edu
Title
Cited by
Cited by
Year
Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A
LJ Byrnes, H Sondermann
Proceedings of the National Academy of Sciences 108 (6), 2216-2221, 2011
2012011
Structural basis for conformational switching and GTP loading of the large G protein atlastin
LJ Byrnes, A Singh, K Szeto, NM Benvin, JP O'donnell, WR Zipfel, ...
The EMBO journal 32 (3), 369-384, 2013
1122013
The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition
J Hall, EC Ralph, S Shanker, H Wang, LJ Byrnes, R Horst, J Wong, ...
Protein Science 26 (12), 2367-2380, 2017
682017
The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2′′-Phosphotransferase-IIa [APH(2′′)-IIa] Provide …
PG Young, R Walanj, V Lakshmi, LJ Byrnes, P Metcalf, EN Baker, ...
Journal of bacteriology 191 (13), 4133-4143, 2009
682009
Circular permutation of red fluorescent proteins
B Shui, Q Wang, F Lee, LJ Byrnes, DM Chudakov, SA Lukyanov, ...
PLoS One 6 (5), e20505, 2011
472011
Sites associated with Kalydeco binding on human cystic fibrosis transmembrane conductance regulator revealed by hydrogen/deuterium exchange
LJ Byrnes, Y Xu, X Qiu, JD Hall, GM West
Scientific Reports 8 (1), 4664, 2018
342018
Aminoglycoside 2′′-phosphotransferase IIIa (APH (2′′)-IIIa) Prefers GTP over ATP: structural templates for nucleotide recognition IN the bacterial AMINOGLYCOSIDE-2′′ kinases
CA Smith, M Toth, H Frase, LJ Byrnes, SB Vakulenko
Journal of Biological Chemistry 287 (16), 12893-12903, 2012
342012
Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy
JD Hall, H Wang, LJ Byrnes, S Shanker, K Wang, IV Efremov, PA Chong, ...
Protein Science 25 (2), 360-373, 2016
322016
Versatile membrane deformation potential of activated pacsin
SL Goh, Q Wang, LJ Byrnes, H Sondermann
PLoS one 7 (12), e51628, 2012
302012
Molecular mechanism of a green-shifted, pH-dependent red fluorescent protein mKate variant
Q Wang, LJ Byrnes, B Shui, UF Röhrig, A Singh, DM Chudakov, ...
PloS one 6 (8), e23513, 2011
192011
A hereditary spastic paraplegia–associated atlastin variant exhibits defective allosteric coupling in the catalytic core
JP O’Donnell, LJ Byrnes, RB Cooley, H Sondermann
Journal of Biological Chemistry 293 (2), 687-700, 2018
152018
In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance
Y Zhu, I Yurgelonis, S Noell, Q Yang, S Guan, Z Li, L Hao, H Rothan, ...
Science advances 10 (30), eadl4013, 2024
92024
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir
SR Greenfield, H Eng, Q Yang, C Guo, L Byrnes, A Dantonio, G West, L Di, ...
Xenobiotica 53 (1), 12-24, 2023
62023
The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation
CM Kelly, LJ Byrnes, N Neela, H Sondermann, JP O’Donnell
Journal of Cell Biology 220 (11), 2021
42021
Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2′′-phosphotransferase-Ic [APH (2′′)-Ic] from Enterococcus gallinarum
LJ Byrnes, A Badarau, SB Vakulenko, CA Smith
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2008
32008
Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism
LJ Byrnes, WY Choi, P Balbo, ME Banker, J Chang, S Chen, X Cheng, ...
ACS Chemical Biology 19 (10), 2186-2197, 2024
2024
2324 From chaperonins to Rubisco assembly and metabolic repair Manajit Hayer-Hartl
J Hall, EC Ralph, S Shanker, H Wang, LJ Byrnes, R Horst, J Wong, ...
PROTEIN SCIENCE 26, 2323-2323, 2017
2017
Aminoglycoside 2 inch-Phosphotransferase IIIa (APH (2-inch) IIIa) Prefers GTP over ATP Structural Templates for Nucleotide Recognition in the Bacterial Aminoglycoside-2 inch …
CA Smith, M Toth, H Frase, LJ Byrnes, SB Vakulenko
J. Biol. Chem. 287: 12893-12903, 2012, 2013
2013
Molecular basis for nucleotide-dependent conformational changes of the large GTPase atlastin
LJ Byrnes
Cornell University, 2013
2013
Crystallographic Studies of Two Bacterial AntibioticResistance Enzymes: Aminoglycoside Phosphotransferase (2')-Ic and GES-1\beta-lactamase
L Brynes
J. Undergrad. Stud., 2007
2007
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