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Marc J Williams
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Identification of neutral tumor evolution across cancer types
MJ Williams, B Werner, CP Barnes, TA Graham, A Sottoriva
Nature Genetics, 2016
6942016
Quantification of subclonal selection in cancer from bulk sequencing data
MJ Williams, B Werner, T Heide, C Curtis, CP Barnes, A Sottoriva, ...
Nature Genetics, 1, 2018
2532018
Evolutionary history of human colitis-associated colorectal cancer
AM Baker, W Cross, K Curtius, I Al Bakir, CHR Choi, HL Davis, D Temko, ...
Gut, gutjnl-2018-316191, 2018
1562018
Ovarian cancer mutational processes drive site-specific immune evasion
I Vázquez-García, F Uhlitz, N Ceglia, JLP Lim, M Wu, N Mohibullah, ...
Nature, 1-9, 2022
1482022
Subclonal reconstruction of tumors by using machine learning and population genetics
G Caravagna, T Heide, MJ Williams, L Zapata, D Nichol, K Chkhaidze, ...
Nature Genetics 52 (9), 898-907, 2020
1092020
Clonal fitness inferred from time-series modelling of single-cell cancer genomes
S Salehi, F Kabeer, N Ceglia, M Andronescu, MJ Williams, KR Campbell, ...
Nature, 1-6, 2021
1082021
Evolutionary dynamics of neoantigens in growing tumours
E Lakatos, MJ Williams, RO Schenck, WCH Cross, J Househam, ...
Nature Genetics 52 (10), 1057-1066, 2020
1072020
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen …
D Temko, IC Van Gool, E Rayner, M Glaire, S Makino, M Brown, ...
The Journal of pathology, 2018
1042018
Single-cell genomic variation induced by mutational processes in cancer
T Funnell, CH O’Flanagan, MJ Williams, A McPherson, S McKinney, ...
Nature, 1-10, 2022
86*2022
Measuring Clonal Evolution in Cancer with Genomics
MJ Williams, A Sottoriva, TA Graham
Annual Review of Genomics and Human Genetics 20, 2019
852019
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
K Chkhaidze, T Heide, B Werner, MJ Williams, W Huang, G Caravagna, ...
PLoS Computational Biology 15 (7), e1007243, 2019
772019
Measuring single cell divisions in human tissues from multi-region sequencing data
B Werner, J Case, MJ Williams, K Chkhaidze, D Temko, ...
Nature communications 11 (1), 1-9, 2020
672020
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
L Zapata, G Caravagna, MJ Williams, E Lakatos, K AbdulJabbar, ...
Nature Genetics 55 (3), 451-460, 2023
44*2023
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
I Sequeira, M Rashid, IM Tomás, MJ Williams, TA Graham, DJ Adams, ...
Nature communications 11 (1), 1-13, 2020
402020
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
MJ Williams, L Zapata, B Werner, C Barnes, A Sottoriva, TA Graham
eLife, 661264, 2020
402020
MLH1 deficiency leads to deregulated mitochondrial metabolism
S Rashid, MO Freitas, D Cucchi, G Bridge, Z Yao, L Gay, M Williams, ...
Cell death & disease 10 (11), 1-11, 2019
402019
Cancer phylogenetic tree inference at scale from 1000s of single cell genomes
S Salehi, F Dorri, K Chern, F Kabeer, N Rusk, T Funnell, MJ Williams, ...
Peer Community Journal 3, 2023
39*2023
Crypt fusion as a homeostatic mechanism in the human colon
AM Baker, C Gabbutt, MJ Williams, B Cereser, N Jawad, ...
Gut, gutjnl-2018-317540, 2019
382019
Reply to ‘Neutral tumor evolution?’
T Heide, L Zapata, MJ Williams, B Werner, G Caravagna, CP Barnes, ...
Nature genetics 50 (12), 1633, 2018
322018
Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer
W Cross, M Mossner, S Nowinski, G Cresswell, A Banerjee, M Williams, ...
bioRxiv, 2020
162020
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Articles 1–20